The first-generation of the Ford F-Series is a series of trucks that was produced by Ford in North America from 1947 to 1952.

The introduction of the F-Series marked the divergence of Ford car and truck design, developing a chassis intended specifically for truck use.

Across North America, Ford assembled F-Series trucks at sixteen different facilities during its production. In Canada, Lincoln-Mercury sold the F-Series under the Mercury M-Series nameplate to expand coverage in rural areas.

In Australia, the trucks were shipped as components from Canada to Geelong, Victoria where they were assembled in the Ford factory before being sent to Ford dealers around the country.

The first generation of the F-Series is the sole generation produced entirely with "Flathead" engines (inline-6 and V8) and without an automatic transmission option.